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The three sCJD cases (a, b; c, d; e, f) are pathology proven. Development of hypertension The RASis directly involved in renovascular hypertension:plasma renin activity (PRA) is raised in mostpatients.

This had been for-merly accepted for postexposure prophylaxis for humanimmunodeficiency virus and low density-lipoprotein(LDL)-cholesterol levels but now convenience andacceptance of only “evidence-based” treatment algo-rithms have led to revision of both of these strategies(28,29).